ASia Pacific Evaluation of Chest pain Trial (ASPECT)

The purpose of this study is to validate in patients presenting to hospital with symptoms suggestive of possible ACS (but without ECG changes of STEMI) that a clinical pathway (‘accelerated chest pain algorithm’) of using ECG and/or Risk Stratification Tools in conjunction with serial biomarkers (with blood levels of Troponin I, CKMB ‘Delta’, and Myoglobin ‘Delta’ measurements) over a 2 hour time period from presentation at hospital will allow the identification of patients at very low risk of serious adverse cardiac event at 30 days after initial presentation.

Between 200 and 1000 subjects are expected to be enrolled at each site.  With a total enrolment for ASPECT study projected goal of 5,400 patients, recruitment began at the end of 2008 and is continuing.