UNIVERSE Study

Despite the widespread use of statins in cardiovascular disease, it is not known whether these agents are of benefit in patients with established chronic heart failure (CHF).  The UNIVERSE study is examining the effect of statins on ventricular remodelling, an important surrogate for clinical outcomes in CHF.  The study compared a high dose of rosuvastatin (40mg/day) versus placebo additional to best practice background therapy.  The results were presented at the American College of Cardiology Meeting in 2006 and published in J Cardiac Failure, 2007.